Applied Continuum Modeling of (Sub)cellular Morphogenesis

Abstract: Cellular phenomena at the microscopic level are usually modeled via molecular simulations. These simulations have the advantage of giving an accurate description of the molecular interactions that give rise to biological phenomena. However, they are computationally expensive and hard to interpret. In particular, they are not capable of giving a satisfactory view of slow processes, such as organelle morphogenesis or cell division. For this purpose, continuum models are preferable. These models can be validated by structural data (e.g. electron microscopy). However, they can also be directly parametrized by molecular simulations. I present such a "data-driven" model for large membrane deformations, e.g. induced by cell penetrating peptides as well as a more reductive morphoelastic model for bacterial division.

MathematicsPhysics

Audience: researchers in the topic

Nečas Seminar on Continuum Mechanics

Series comments: This seminar was founded on December 14, 1966.

Faculty of Mathematics and Physics, Charles University, Sokolovská 83, Prague 8. If not written otherwise, we will meet on Mondays at 15:40 in lecture hall K3 (2nd floor)