Modeling of carotid artery hemodynamics towards a CFD database for stroke risk assessment

Abstract: In medicine, the risk assessment of strokes caused by pathological irregularities in the bifurcation of the carotid artery plays a major role in the patient's optimal treatment decision. This decision-making process can be greatly enhanced by detailed flow field data obtained from simulations using patient-specific arterial morphologies. We present our numerical modeling approach to create a CFD database that can guide stroke risk assessment, including hemodynamic shear risk metrics. We investigate the multi-directional behavior of wall shear stress (WSS) based on specially constructed longitudinal tangent vectors using a center-line projection approach and present the utility of longitudinal WSS evaluation for detecting opposing or transverse WSS in slow patient-specific flow. In our fluid-structure interaction model, we generalize the assumption of linear elasticity by a strain-dependent elastic modulus that is consistent with laboratory measurements of compliance and distensibility. Finally, we present the established working pipeline to generate CFD data for a large number of patient-specific geometries. Created hemodynamic datasets can be used for visual atlases and comparative analysis or explored by neural networks.

MathematicsPhysics

Audience: researchers in the topic

Nečas Seminar on Continuum Mechanics

Series comments: This seminar was founded on December 14, 1966.

Faculty of Mathematics and Physics, Charles University, Sokolovská 83, Prague 8. If not written otherwise, we will meet on Mondays at 15:40 in lecture hall K3 (2nd floor)