RNA Biology at the crossroads of evolution and disease

Prof. Dr. Jernej Ule (Francis Crick Institute)

08-Jan-2021, 10:00-11:00 (3 years ago)

Abstract: The talk will introduce the techniques that can be used to investigate the assembly and function of ribonucleoprotein complexes (RNPs). This includes iCLIP, a method combining multi-step biochemistry and computational biology to obtain a comprehensive map of protein-RNA interactions within cells. I will also present our study of disease-causing mutations in TDP-43, a protein that is often mutated in amyotrophic lateral sclerosis. The mutations tend to be located within intrinsically disordered regions, and I will present the roles of these regions in fine-tuning the RNA binding properties and functions of the protein. Moreover, I will present our work on the roles that transposable elements play in RNP assembly. I will discuss how these aspects of protein-RNA interactions contribute to regulatory variation, and thus play important roles in evolution and disease.

cell biologygeneticsmolecular biology

Audience: researchers in the discipline

( video )


Colloquium zooming Molecular & Cellular Biology LUMS

Series comments: Zooming Molecular & Cellular Biology Colloquium was initiated on July 28th, 2020 by the Biology department at Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS). The series follows through various topics which come under the ambit of Molecular and Cellular Biology and we’ve had the pleasure and honor of hosting some of the most knowledgeable scientists from around the globe. Organizers can be reached out at 24100162@lums.edu.pk or 24100001@lums.edu.pk for the Zoom link of individual talks. All lectures are LIVE streamed on SBASSE's official Facebook page.

Organizers: Prof. Dr. Muhammad Tariq, Salman Tuasene Khawaja*, Hooraina Hassan Siddiqui*, Abdullah Jauhar*
*contact for this listing

Export talk to