Functional Organization of the Genome in 3D

Abstract: The three-dimensional organisation of the genome is tightly linked to its function. The cell-type specific folding of the DNA enables gene regulatory elements, including promoters and enhancers, to interact, in some cases bridging distances of hundreds of kilobases. These enhancer-promoter contacts are thought to be crucial for gene expression control. I will discuss recent progress in the methodology to map the 3D organisation of chromatin in mammalian nuclei genome-wide, illustrate on examples how enhancer-promoter contacts dynamically respond to signalling cues and are rewired during cell fate transitions, and highlight some of the major challenges and open questions in the field.

cell biologygeneticsmolecular biology

Audience: researchers in the discipline

( video )

Colloquium zooming Molecular & Cellular Biology LUMS

Series comments: Zooming Molecular & Cellular Biology Colloquium was initiated on July 28th, 2020 by the Biology department at Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS). The series follows through various topics which come under the ambit of Molecular and Cellular Biology and we’ve had the pleasure and honor of hosting some of the most knowledgeable scientists from around the globe. Organizers can be reached out at 24100162@lums.edu.pk or 24100001@lums.edu.pk for the Zoom link of individual talks. All lectures are LIVE streamed on SBASSE's official Facebook page.