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SUMMARY:Dr. Stefan Schoenfelder (Babraham Institute\, Cambridge)
DTSTART:20200911T100000Z
DTEND:20200911T120000Z
DTSTAMP:20260423T024547Z
UID:MCB_LUMS/3
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MCB_LUMS/3/"
 >Functional Organization of the Genome in 3D</a>\nby Dr. Stefan Schoenfeld
 er (Babraham Institute\, Cambridge) as part of Colloquium zooming Molecula
 r & Cellular Biology LUMS\n\n\nAbstract\nThe three-dimensional organisatio
 n of the genome is tightly linked to its function. The cell-type specific 
 folding of the DNA enables gene regulatory elements\, including promoters 
 and enhancers\, to interact\, in some cases bridging distances of hundreds
  of kilobases. These enhancer-promoter contacts are thought to be crucial 
 for gene expression control. I will discuss recent progress in the methodo
 logy to map the 3D organisation of chromatin in mammalian nuclei genome-wi
 de\, illustrate on examples how enhancer-promoter contacts dynamically res
 pond to signalling cues and are rewired during cell fate transitions\, and
  highlight some of the major challenges and open questions in the field.\n
LOCATION:https://researchseminars.org/talk/MCB_LUMS/3/
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