Transcriptomics for Personalized Medicine

Prof. Dr. Gregory Gibson (Georgia Institute of Technology)

09-Feb-2021, 13:00-14:00 (3 years ago)

Abstract: Transcriptomics is the study of gene expression. It has enormous potential to understand the molecular basis of disease and to help guide therapeutic intervention. These day, RNA sequencing (scRNAseq) can be used to profile gene expression in thousands of individual cells, allowing reserarchers to characterize which cell types are modified in patients destined to progress to complicated disease. By combining transcriptomics with genome-wide association studies (TWAS), we can identify causal genes that are involved in pathogenesis. I will discuss recent findings from my group in relation to inflammatory bowel disease, a chronic disease of the gut which is increasing in prevalence all over the world. Specific genetic signatures predict disease progression, including the need for colectomy, and might be used to guide medication usage to those in most need or most likely to respond. I will also describe a new approach to studying how polygenic risk interacts with environmental exposures to influence risk of complicated disease.

biochemistrycancer biologychemical biologycell biologydevelopmental biologydrug discoveryevolutiongeneticsimmunologymolecular biologymicrobiologyneuroscienceplant sciencessystems biologybiotechnologybiological techniquesbiophysics

Audience: researchers in the discipline

( video )

Comments: Organizers can be contacted at m.tariq@lums.edu.pk or 22100032@lums.edu.pk for the zoom link.


Colloquium zooming Molecular & Cellular Biology LUMS

Series comments: Zooming Molecular & Cellular Biology Colloquium was initiated on July 28th, 2020 by the Biology department at Syed Babar Ali School of Science & Engineering (SBASSE), Lahore University of Management Sciences (LUMS). The series follows through various topics which come under the ambit of Molecular and Cellular Biology and we’ve had the pleasure and honor of hosting some of the most knowledgeable scientists from around the globe. Organizers can be reached out at 24100162@lums.edu.pk or 24100001@lums.edu.pk for the Zoom link of individual talks. All lectures are LIVE streamed on SBASSE's official Facebook page.

Organizers: Prof. Dr. Muhammad Tariq, Salman Tuasene Khawaja*, Hooraina Hassan Siddiqui*, Abdullah Jauhar*
*contact for this listing

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