BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Gregory Gibson (Georgia Institute of Technology) DTSTART:20210209T130000Z DTEND:20210209T140000Z DTSTAMP:20260423T024743Z UID:MCB_LUMS/13 DESCRIPTION:Title: Transcriptomics for Personalized Medicine\nby Prof. Dr. Gregory Gibs on (Georgia Institute of Technology) as part of Colloquium zooming Molecul ar & Cellular Biology LUMS\n\n\nAbstract\nTranscriptomics is the study of gene expression. It has enormous potential to understand the molecular ba sis of disease and to help guide therapeutic intervention. These day\, RN A sequencing (scRNAseq) can be used to profile gene expression in thousand s of individual cells\, allowing reserarchers to characterize which cell t ypes are modified in patients destined to progress to complicated disease. By combining transcriptomics with genome-wide association studies (TWAS) \, we can identify causal genes that are involved in pathogenesis. I will discuss recent findings from my group in relation to inflammatory bowel d isease\, a chronic disease of the gut which is increasing in prevalence al l over the world. Specific genetic signatures predict disease progression \, including the need for colectomy\, and might be used to guide medicatio n usage to those in most need or most likely to respond. I will also desc ribe a new approach to studying how polygenic risk interacts with environm ental exposures to influence risk of complicated disease.\n\nOrganizers ca n be contacted at m.tariq@lums.edu.pk or 22100032@lums.edu.pk for the zoom link.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/13/ END:VEVENT END:VCALENDAR