Analysis of genetic-metabolic circuits using piecewise affine dynamical systems

Abstract: Cell survival depends on the interplay of biochemical networks that sense, transmit and process environmental cues. In particular, the interplay between metabolism and gene regulatory networks allows cells to switch on or off specific pathways in response to changing environmental conditions. This control strategy typically appears in the form of feedback loops where key regulatory metabolites up- or down-regulate enzyme expression. In this talk I will present some of our work on the analysis and design of coupled genetic-metabolic networks. I will show how to timescale separation and piecewise constant approximations can be jointly employed to predict the long-term dynamics nonlinear models with complex combinations of positive and negative feedback loops. This work results from a long-term collaboration with Madalena Chaves at INRIA Sophia Antipolis, see e.g Chaves & Oyarzún, Automatica, 2019.

algebraic geometrydynamical systemsprobability

Audience: researchers in the topic

( video )

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Seminar on the Mathematics of Reaction Networks

Series comments: Subscription link: list.ku.dk/postorius/lists/morn.list.ku.dk/

This seminar series focuses on progress in mathematical theory for the study of reaction networks, mainly in biology and chemistry. The scope is broad and accommodates works arising from dynamical systems, stochastics, algebra, topology and beyond.

We aim at providing a common forum for sharing knowledge and encouraging discussion across subfields. In particular we aim at facilitating interactions between junior and established researchers. These considerations will be represented in the choice of invited speakers and we will strive to create an excellent, exciting and diverse schedule.

The seminar runs twice a month, typically on the 2nd and 4th Thursday of the month, at 17:00 Brussels time (observe that this webpage shows the schedule in your current time zone). Each session consists of two 25-minute talks followed by 5-minute questions. After the two talks, longer discussions will take place for those interested. To this end, we will use breakout rooms. For this to work well, you need to have the latest version of Zoom installed (version 5.3.0 or higher), and use the desktop client or mobile app (not supported on ChromeOS).

We look forward hearing about new work and meeting many of you over zoom! Many of the talks are recorded; to see the recording, from Past Talks, open details of the listed talk for a video link.

The organizers.

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