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SUMMARY:Diego Oyarzun (University of Edinburgh)
DTSTART:20240314T160000Z
DTEND:20240314T163000Z
DTSTAMP:20260421T124112Z
UID:MoRN/89
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MoRN/89/">An
 alysis of genetic-metabolic circuits using piecewise affine dynamical syst
 ems</a>\nby Diego Oyarzun (University of Edinburgh) as part of Seminar on 
 the Mathematics of Reaction Networks\n\n\nAbstract\nCell survival depends 
 on the interplay of biochemical networks that sense\, transmit and process
  environmental cues. In particular\, the interplay between metabolism and 
 gene regulatory networks allows cells to switch on or off specific pathway
 s in response to changing environmental conditions. This control strategy 
 typically appears in the form of feedback loops where key regulatory metab
 olites up- or down-regulate enzyme expression. In this talk I will present
  some of our work on the analysis and design of coupled genetic-metabolic 
 networks. I will show how to timescale separation and piecewise constant a
 pproximations can be jointly employed to predict the long-term dynamics no
 nlinear models with complex combinations of positive and negative feedback
  loops. This work results from a long-term collaboration with Madalena Cha
 ves at INRIA Sophia Antipolis\, see e.g Chaves & Oyarzún\, Automatica\, 2
 019.\n
LOCATION:https://researchseminars.org/talk/MoRN/89/
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