Free energy transduction in chemical reaction networks from enzymes to metabolism

Massimiliano Esposito (University of Luxembourg)

24-Mar-2022, 16:30-17:00 (2 years ago)

Abstract: I will rigorously define energy transduction in open chemical reaction networks (CRNs). The method is based on the stoichiometric matrix and the chemostatted species to identify the fundamental set of thermodynamic forces and fluxes contributing to the CRN dissipation at steady state. Transduction arises when some fluxes flow against their force thus creating negative contributions to the dissipation. This is possible because other fluxes power transduction by being aligned with their force and ensuring the overall positivity of the dissipation. Transduction is an emergent phenomenon arising at the network level because fluxes of elementary reactions are always aligned with their force. I will apply our method to study the efficiency of metabolic pathways in central metabolism. Our method generalizes to arbitrary (nonlinear) CRNs the work by Terrell L. Hill on free energy transduction in pseudo first order (linear) CRNs.

algebraic geometrydynamical systemsprobability

Audience: researchers in the topic

( video )


Seminar on the Mathematics of Reaction Networks

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This seminar series focuses on progress in mathematical theory for the study of reaction networks, mainly in biology and chemistry. The scope is broad and accommodates works arising from dynamical systems, stochastics, algebra, topology and beyond.

We aim at providing a common forum for sharing knowledge and encouraging discussion across subfields. In particular we aim at facilitating interactions between junior and established researchers. These considerations will be represented in the choice of invited speakers and we will strive to create an excellent, exciting and diverse schedule.

The seminar runs twice a month, typically on the 2nd and 4th Thursday of the month, at 17:00 Brussels time (observe that this webpage shows the schedule in your current time zone). Each session consists of two 25-minute talks followed by 5-minute questions. After the two talks, longer discussions will take place for those interested. To this end, we will use breakout rooms. For this to work well, you need to have the latest version of Zoom installed (version 5.3.0 or higher), and use the desktop client or mobile app (not supported on ChromeOS).

We look forward hearing about new work and meeting many of you over zoom!

The organizers.

Organizers: Daniele Cappelletti*, Stefan Müller*, Tung Nguyen*, Polly Yu*
*contact for this listing

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