BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Kelly Maggs (Max Planck Institute of Molecular Cell Biology and Ge netics) DTSTART:20260608T080000Z DTEND:20260608T090000Z DTSTAMP:20260604T173309Z UID:TropicalmathandML/39 DESCRIPTION:Title: Cohomology classes in the transcriptome\nby Kelly Maggs (Ma x Planck Institute of Molecular Cell Biology and Genetics) as part of Trop ical mathematics and machine learning\n\n\nAbstract\nSingle-cell sequencin g data consists of a point cloud where the points are cells\, with coordin ates RNA expression levels in each gene. Since the tissue is destroyed by the sequencing procedure\, the dynamics of gene expression must be inferre d from the structure and geometry of the point cloud. In this talk\, we wi ll build a biological interpretation of the one-dimensional cohomology cla sses in hallmark gene subsets as models for biological processes. Such pro cesses include the cell-cycle\, but more generally model homeostatic negat ive feedback loops. Our procedure uses persistent cohomology to identify f eatures\, and integration of differential forms to estimate the cascade of genes associated with the underlying dynamics of gene expression.\n LOCATION:https://researchseminars.org/talk/TropicalmathandML/39/ END:VEVENT END:VCALENDAR