BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Anotida Madzvamuse (UBC-O hosted) (UBC) DTSTART:20250529T210000Z DTEND:20250529T220000Z DTSTAMP:20260513T193639Z UID:SFUOR/55 DESCRIPTION:Title: U sing geometric bulk-surface PDEs for insilico modelling of single and coll ective cell migration\nby Anotida Madzvamuse (UBC-O hosted) (UBC) as p art of PIMS-CORDS SFU Operations Research Seminar\n\nLecture held in ASB 1 0908.\n\nAbstract\nIn this talk\, I will present insilico models for 2- an d 3-D cell migration\, from single to collective\, based on geometric bulk -surface partial differential equations (G-BS-PDEs). The first model is a geometric surface PDE approach where the cell is described by its cell mem brane which obeys a force balance equation for its evolution. This approac h encodes naturally the biochemical processes and biomechanical properties of the cells and its interactions with deformable obstacles\, and cell-to -cell interactions. I will also present a generalisation to include interi or cell dynamics for cells migrating in confinement. The second model cons ists of an optimal control model based on geometric multigrid methods for a diffuse-interface formulation. This approach allows us to model the spat iotemporal dynamics of static experimental images of migrating cells. A by -product of this methodology is the automatic quantification of proliferat ion rates associated with cell division. A third and final approach is a v iscoelastic model\, where the displacements of the cell are driven by biom olecular species which obey a reaction-diffusion system. Numerical results will be presented to illustrate the novelty of these mechanobiochemical m odels for single and collective cell migration. Single and collective cell migration are essential for physiological\, pathological and biomedical p rocesses in development\, repair\, and disease\, for example\, in embryoge nesis\, wound healing\, immune response\, cancer metastasis\,\ntumour inva sion\, and inflammation.\n LOCATION:https://researchseminars.org/talk/SFUOR/55/ END:VEVENT END:VCALENDAR