BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Ashwin Gopinath (Assistant Professor\, Mechanical Engineering (Mec hE)) DTSTART:20200921T175000Z DTEND:20200921T180500Z DTSTAMP:20260423T005831Z UID:SENSEnano/1 DESCRIPTION:Title: Democratizing single molecule nanoarrays\nby Ashwin Gopinath (Assist ant Professor\, Mechanical Engineering (MechE)) as part of SENSE.nano Symp osium from MIT.nano\n\n\nAbstract\nArrays of individual molecules or nanop articles can combine the advantage of microarrays and single-molecule expe riments. They facilitate miniaturized high-throughput assays with low samp le and reagent consumption while also revealing heterogeniety hidden in en semble measurements. However\, creating single molecule arrays are particu larly difficult since conventional nano-fabrication techniques can't be us ed to organize individual molecules onto defined positions on a substrate. In this context 'DNA origami placement' is an appealing technique as it a llows any molecule (or nanoparticle) that can be labeled with DNA to be or ganized on arbitrary substrates using standard lithographic processes. The challenge now becomes one of reducing cost\, developing applications\, an d increasing the capabilities.\n\nIn this talk\, Gopinath will introduce a bench-top technique to create cm-scale DNA origami nanoarrays that does n ot require any nanopatterning step\, at a cost of $1 per cm2 and Gopinath will also discuss the application of this technique for point-of-care diag nostics. Finally\, Gopinath will end by introducing strategies for perform ing non-aqueous organic reaction on immobilized DNA origami for creating a rrays of extremely hydrophobic molecules.\n LOCATION:https://researchseminars.org/talk/SENSEnano/1/ END:VEVENT END:VCALENDAR