BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Radek Erban (University of Oxford) DTSTART:20261123T144000Z DTEND:20261123T161000Z DTSTAMP:20261113T192939Z UID:NSCM/219 DESCRIPTION:Title: M ultiresolution Modelling of Intracellular Processes\nby Radek Erban (U niversity of Oxford) as part of Nečas Seminar on Continuum Mechanics\n\nI nteractive livestream: https://cesnet.zoom.us/j/94319936814?pwd=Y0pRL0FpWE hhQ1U4TzZGc2FDQVM4Zz09\nView-only livestream: https://www.youtube.com/chan nel/UCn9vmevniyXXLEr7VBp5cCQ\nLecture held in Room K3\, Faculty of Mathem atics and Physics\, Charles University\, Sokolovská 83 Prague 8..\n\nAbs tract\nSpatio-temporal modelling of biological processes inside living cel ls relies on mathematical and computational methods that differ in the lev el of biological detail they capture. In my talk\, I will discuss modellin g approaches ranging from all-atom molecular dynamics simulations to macro scopic mean-field models described by partial differential equations (PDEs )\, with intermediate (mesoscopic) approaches including Brownian dynamics and stochastic coarse-grained models. In some cases\, rigorous connections between these modelling frameworks can be established by deriving macrosc opic descriptions from more detailed models. I will discuss these connecti ons\, focusing on the development\, analysis\, and applications of multire solution methods that combine detailed (high-resolution) simulations in lo calized regions of particular interest\, where accuracy and microscopic de tail are crucial\, with coarser macroscopic models elsewhere\, where some accuracy can be traded for computational efficiency. I will illustrate the se methodologies through applications to intracellular calcium dynamics\, actin dynamics\, and DNA dynamics.\n LOCATION:https://researchseminars.org/talk/NSCM/219/ URL:https://cesnet.zoom.us/j/94319936814?pwd=Y0pRL0FpWEhhQ1U4TzZGc2FDQVM4Z z09 URL:https://www.youtube.com/channel/UCn9vmevniyXXLEr7VBp5cCQ END:VEVENT END:VCALENDAR