BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:J. Krishnan (Imperial College London) DTSTART:20231109T160000Z DTEND:20231109T163000Z DTSTAMP:20260421T124420Z UID:MoRN/81 DESCRIPTION:Title: Sy stems explorations of substrate modification systems\nby J. Krishnan ( Imperial College London) as part of Seminar on the Mathematics of Reaction Networks\n\n\nAbstract\nThe post-translational modification of proteins i s a basic way of establishing protein functionality. There are many exampl es of classes of reversible modification (phosphorylation\, ubiquination\, acetylation). Typically proteins are reversibly modified at multiple site by associated enzymes. In some instances\, the same enzymes can perform m ultiple modifications or demodifications. In such cases\, different types of chemical mechanisms are possible: distributive\, wherein each modificat ion is associated with the enzyme binding to the substrate\, and then diss ociating after the modification\, and processive wherein the enzyme is bou nd to the substrate as multiple modifications are effected. Substrate modi fications could also occur in a particular sequence (ordered)\, or could o ccur in any order (random).\n\nInterest in substrate modification systems arises from the fact that they are fundamental ingredients of cellular net works on one hand\, while also being complex molecular information proces sors in their own right. In this talk\, we discuss various aspects of the information processing characteristics of substrate modification systems. We first discuss some aspects of the intrinsic behaviour of these substrat e modification systems and connect them to basic ingredients (eg. chemical mechanism\, substrate modification ordering\, commonality of enzymes). Fo llowing this\, we discuss how such substrate modification systems may beh ave as part of networks. We discuss the relevance of the results and insig hts for both systems and synthetic biology\n\n(Joint work with Vaidhiswara n Ramesh and Thapanar Suwanmajo).\n LOCATION:https://researchseminars.org/talk/MoRN/81/ END:VEVENT END:VCALENDAR