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SUMMARY:Irene Otero Muras (Institute for Integrative Systems Biology)
DTSTART:20220428T150000Z
DTEND:20220428T153000Z
DTSTAMP:20260421T123923Z
UID:MoRN/48
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MoRN/48/">De
 tection of bistability in biochemical reaction networks: from mass action 
 to arbitrary kinetics\, and from deterministic to stochastic regimes</a>\n
 by Irene Otero Muras (Institute for Integrative Systems Biology) as part o
 f Seminar on the Mathematics of Reaction Networks\n\n\nAbstract\nIn this t
 alk\, I will describe the mathematical conditions and algorithms that we h
 ave developed over the last decade (together with Antonio A. Alonso) for t
 he detection of multistationarity and bistability in biochemical reaction 
 networks: from a condition for multistationarity for biochemical reaction 
 networks with mass action kinetics\, to the most recent developments in bi
 stability detection for networks of arbitrary kinetics. Our approach relie
 s on concepts from Chemical Reaction Network Theory\, Bifurcation Theory a
 nd Nonlinear Optimization. I will explain the relevance of bistability in 
 the context of cell decision making\, and how cell decisions and bistabili
 ty are affected in the presence of molecular noise.\n\nMoreover\, I will i
 llustrate the specific biological problems that we have solved in the cont
 ext of systems and synthetic biology using tools for efficient bistability
  detection (like elucidating mechanisms responsible for differential signa
 lling\, or designing programmable genetic biosensors in bacteria).\n
LOCATION:https://researchseminars.org/talk/MoRN/48/
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