BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Lea Sta (University of Leeds) DTSTART:20220224T160000Z DTEND:20220224T163000Z DTSTAMP:20260421T124447Z UID:MoRN/45 DESCRIPTION:Title: Ma thematical modelling of a receptor-ligand system\nby Lea Sta (Universi ty of Leeds) as part of Seminar on the Mathematics of Reaction Networks\n\ n\nAbstract\nEffector T cells rely on IL-7 signalling for their survival. The IL-7 receptor (IL-7R)\, composed of the common gamma chain and the spe cific alpha chain\, is also associated with the kinase JAK3 which triggers its signalling pathway. Recent single-cell analysis showed a seemingly pa radoxical observation: increased availability of gamma chains reduces the IL-7 response. We describe two IL-7R mathematical models that provides an explanation for this inhibitory activity and shows that a balance between the IL-7R subunits is crucial for optimal signaling. Use of the Groebner b asis provides analytical expressions for the maximum IL-7 response (or amp litude) and for the half maximal effective concentration (EC50) of our mod els. The results obtained inspired the study of a more general family of s equential models of receptor with extrinsic kinase.\n LOCATION:https://researchseminars.org/talk/MoRN/45/ END:VEVENT END:VCALENDAR