BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Ankit Gupta (ETH Zurich) DTSTART:20241010T153000Z DTEND:20241010T160000Z DTSTAMP:20260421T123940Z UID:MoRN/103 DESCRIPTION:Title: C omplete characterization of kinetics-independent robust perfect adaptation in biochemical reaction networks\nby Ankit Gupta (ETH Zurich) as part of Seminar on the Mathematics of Reaction Networks\n\n\nAbstract\nBiologi cal cells must precisely regulate the levels of key biomolecular species t o survive and perform their functions. A specific form of this regulation is Robust Perfect Adaptation (RPA)\, where certain species maintain certai n levels despite external disturbances\, without the need to fine-tune the system’s parameters. Although RPA has been extensively studied mathemat ically\, identifying it in complex\, high-dimensional networks—along wit h understanding the associated regulatory mechanisms—remains a significa nt challenge.\n\nThis talk introduces a novel approach to identifying all RPA properties that emerge independently of the network’s kinetics in ge neral deterministic reaction networks. The approach demonstrates that each RPA property corresponds to a subnetwork with specific topological charac teristics. By leveraging this connection\, we show that these structures g ive rise to all kinetics-independent RPA properties\, enabling the systema tic identification of all these properties by enumerating such subnetworks . Additionally\, we identify the integral feedback controllers responsible for realizing each RPA property\, framing our findings within the control -theoretic framework of the Internal Model Principle.\n\nThis is joint wor k with Prof. Yuji Hirono (Osaka University) and Prof. Mustafa Khammash (ET H Zürich)\n LOCATION:https://researchseminars.org/talk/MoRN/103/ END:VEVENT END:VCALENDAR