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SUMMARY:Prof. Dr. Helge Grosshans (Friedrich Miescher Institute for Biomed
 ical Research)
DTSTART:20210111T090000Z
DTEND:20210111T100000Z
DTSTAMP:20260423T024614Z
UID:MCB_LUMS/9
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MCB_LUMS/9/"
 >Properties and Functioning of a Developmental Clock</a>\nby Prof. Dr. Hel
 ge Grosshans (Friedrich Miescher Institute for Biomedical Research) as par
 t of Colloquium zooming Molecular & Cellular Biology LUMS\n\n\nAbstract\nT
 he development of an animal requires proper temporal synchronization of di
 verse events\, facilitated by developmental clocks. How such clocks functi
 on is only beginning to emerge. What are their properties? What are the co
 mponents that make them run\, and how are they wired? To solve these quest
 ions\, we investigate developmental timing in the roundworm C. elegans\, w
 here we can exploit our recent discovery that thousands of genes oscillate
  in expression during larval development. Such extensive and robust molecu
 lar clock output\, combined with powerful tools for genetic manipulation a
 nd screening\, makes C. elegans uniquely suited for dissecting the underly
 ing clock mechanism. I will report how our work combining genomics\, genet
 ic and high-throughput single animal-based approaches with theory has unco
 vered a developmental clock with unusual checkpoint properties.\n
LOCATION:https://researchseminars.org/talk/MCB_LUMS/9/
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