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SUMMARY:Prof. Dr. Sandra Hake (JLU Giessen)
DTSTART:20201016T070000Z
DTEND:20201016T090000Z
DTSTAMP:20260423T040004Z
UID:MCB_LUMS/5
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MCB_LUMS/5/"
 >Histones: How much variation do we need?</a>\nby Prof. Dr. Sandra Hake (J
 LU Giessen) as part of Colloquium zooming Molecular & Cellular Biology LUM
 S\n\n\nAbstract\nAll eukaryotes organize their DNA together with histones 
 and non-histone proteins into a highly complex nucleoprotein structure cal
 led chromatin\, with the nucleosome as its monomeric subunit. Several inte
 rconnected mechanisms have evolved to regulate DNA accessibility\, includi
 ng nucleosome replacement of canonical histones with specialized histone v
 ariants. Deposition of histone variants can lead to profound chromatin str
 ucture alterations thereby influencing a multitude of biological processes
  ranging from transcriptional regulation to genome stability. At the focus
  of our research is the evolutionary highly conserved histone variant H2A.
 Z\, which has been extensively studied and shown to play a role in gene ex
 pression\, DNA repair\, heterochromatin formation\, chromosome segregation
  and mitosis. But the mechanism(s) of how H2A.Z controls these diverse bio
 logical processes is not understood. Using state-of-the-art biochemical\, 
 cell biological\, genome-wide and bioinformatics approaches we are sheddin
 g light on H2A.Z biology by identifying its manifold binding proteins and 
 their functional roles in gene regulation\, cell cycle progression and org
 anismal development.\n
LOCATION:https://researchseminars.org/talk/MCB_LUMS/5/
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