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SUMMARY:Prof. Dr. Peter Becker (LMU Munich)
DTSTART:20201009T070000Z
DTEND:20201009T090000Z
DTSTAMP:20260423T024622Z
UID:MCB_LUMS/4
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MCB_LUMS/4/"
 >Genetic & Epigenetic Mechanisms of X Chromosome Activation in Drosophila<
 /a>\nby Prof. Dr. Peter Becker (LMU Munich) as part of Colloquium zooming 
 Molecular & Cellular Biology LUMS\n\n\nAbstract\nThe process of X-chromoso
 me dosage compensation in Drosophila involves boosting the transcription o
 f most genes on the X in male flies to match the transcription output of t
 he two X chromosomes in females. Activation is achieved through histone ac
 etylation of active gene chromatin by the histone acetyltransferase MOF. M
 OF is recruited to its targets by the dosage compensation complex (DCC). A
 ccording to the prevalent model this involves genetic and epigenetic princ
 iples:  the DCC first binds to a defined number of DNA sequence elements\,
  the High Affinity Sites (HAS)\, which are exclusive to the X. The activat
 or then identifies and acetylates active gene chromatin in the nuclear nei
 ghborhood\, presumably through their epigenetic H3K36me3 signature.\n\nDos
 age compensation happens gradually during early embryonic development and 
 matures along with refined chromosome folding. Key to successful dosage co
 mpensation is the property of the DCC to selectively bind the X chromosome
 . We continue to explore the molecular principles that allow such selectiv
 e regulation. Most recently\, we made significant progress in identifying 
 and testing such principles by whole-genome chromatin reconstitution in a 
 cell-free system.\n
LOCATION:https://researchseminars.org/talk/MCB_LUMS/4/
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