BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Sue Biggins (Fred Huch Cancer Center) DTSTART:20230306T150000Z DTEND:20230306T160000Z DTSTAMP:20260423T024619Z UID:MCB_LUMS/32 DESCRIPTION:Title: How do cells inherit the right chromosomes?\nby Prof. Dr. Sue Biggin s (Fred Huch Cancer Center) as part of Colloquium zooming Molecular & Cell ular Biology LUMS\n\n\nAbstract\nThe precise regulation of cell division i s critical to processes such as self-renewal\, proliferation and developme nt. A key event in the cell cycle is the partitioning of every pair of dup licated chromosomes to daughter cells. Chromosomes segregate using their k inetochores\, the specialized protein structures that are assembled on cen tromeric DNA sequences and attach to spindle microtubules. I will discuss our recent advances in isolating and reconstituting kinetochores and stud ying their behavior by biochemical and biophysical techniques in vitro. Th is work showed that tension directly regulates the activity of the Aurora B kinase. In addition\, I will discuss our recent development of a single molecule assay to monitor kinetochore assembly in real time and what it h as revealed about the centromeric nucleosome and the specificity of the ce ntromeric DNA\, work that ultimately is critical to understanding how cell s maintain genomic stability.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/32/ END:VEVENT END:VCALENDAR