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SUMMARY:Prof. Dr. Fred Winston (Harvard Medical School)
DTSTART:20230203T130000Z
DTEND:20230203T140000Z
DTSTAMP:20260423T022804Z
UID:MCB_LUMS/31
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MCB_LUMS/31/
 ">Analysis of factors that control transcriptional fidelity and chromatin 
 structure</a>\nby Prof. Dr. Fred Winston (Harvard Medical School) as part 
 of Colloquium zooming Molecular & Cellular Biology LUMS\n\n\nAbstract\nNuc
 leosomes are barriers for transcription. To help to alleviate these barrie
 rs\, a class of factors called histone chaperones modulates histone-DNA in
 teractions. Our work has focused on set of three histone chaperones that a
 re essential for viability and that are conserved from yeast to humans. Ou
 r studies\, using S. cerevisiae as a model system\, have shown that these 
 three factors\, Spt6\, Spn1\, and FACT\, are broadly required for the fide
 lity of transcription and the integrity of chromatin structure. While all 
 three histone chaperones are vital for growth\, we have found unexpected c
 onnections between their functions that suggest that they interact in a ne
 twork that is critical for their functions in transcription\, as well as o
 ther chromatin-templated functions including DNA replication and genome st
 ability.\n
LOCATION:https://researchseminars.org/talk/MCB_LUMS/31/
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