BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Monica P. Colaiacovo (Harvard Medical School) DTSTART:20221109T140000Z DTEND:20221109T150000Z DTSTAMP:20260423T022812Z UID:MCB_LUMS/29 DESCRIPTION:Title: Location and numbers: how recombination and our chemical landscape conve rge on meiosis\nby Prof. Dr. Monica P. Colaiacovo (Harvard Medical Sch ool) as part of Colloquium zooming Molecular & Cellular Biology LUMS\n\n\n Abstract\nResearch in our laboratory is focused on understanding the regul ation of mechanisms that promote accurate chromosome segregation during me iosis\, such as recombination\, and how exposure to endocrine-disrupting c hemicals (EDCs) affect these mechanisms. Errors in achieving accurate chro mosome segregation during meiosis can result in the formation of aneuploid gametes (i.e.\, eggs and sperm carrying an incorrect number of chromosome s)\, which is associated with miscarriages\, stillbirths\, infertility\, a nd birth defects. Our team has directly demonstrated in a metazoan (the ne matode C. elegans) how the position of DNA double-strand breaks and crosso ver recombination events are critical for accurate chromosome segregation and how exposure to an abundantly used plasticizer (DEHP) alters this regu lation. Ongoing studies are examining what factors regulate the distributi on of recombination events and how other EDCs differentially affect female and male meiosis\, leading to embryonic lethality and infertility.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/29/ END:VEVENT END:VCALENDAR