BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Cedric Maurange (Institute of Developmental Biology of M arseilles) DTSTART:20220608T090000Z DTEND:20220608T103000Z DTSTAMP:20260423T022803Z UID:MCB_LUMS/27 DESCRIPTION:Title: Deconstructing the principles of cellular hierarchy in tumors with a dev elopmental origin\nby Prof. Dr. Cedric Maurange (Institute of Developm ental Biology of Marseilles) as part of Colloquium zooming Molecular & Cel lular Biology LUMS\n\n\nAbstract\nPediatric cancers are different from adu lt cancers in that they carry much fewer genetic lesions but are able to p rogress extremely rapidly. In addition\, brain cancers are over-represente d in children. Recent data has demonstrated that pediatric brain cancers o ften originate during embryonic and fatal stages\, and aberrantly recapitu late sub-parts of developmental programs. It has been proposed that such t umors are « locked » into perpetual development. Yet it is often unclear why these developmental programs become mis-regulated during the course o f development and how they are coopted to promote tumorigenesis. We are ad dressing these questions using a Drosophila model of neural tumors with a developmental origin\, resembling in many aspect pediatric cancers in huma n. Our work has identified the coopted developmental program that sustains tumor growth and has deciphered their hierarchical cellular organization. During my talk\, I will present our recent finding that epigenetic regula tors of the PRC2 and MLL1/2-COMPASS complexes regulate this hierarchy\, an d how their inactivation can trigger plasticity and cancer stem cell heter ogeneity.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/27/ END:VEVENT END:VCALENDAR