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SUMMARY:Prof. Dr. Norbert Perrimon (Harvard University)
DTSTART:20220325T140000Z
DTEND:20220325T150000Z
DTSTAMP:20260423T024728Z
UID:MCB_LUMS/26
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MCB_LUMS/26/
 ">Inter-organ communication: Studies in Drosophila</a>\nby Prof. Dr. Norbe
 rt Perrimon (Harvard University) as part of Colloquium zooming Molecular &
  Cellular Biology LUMS\n\n\nAbstract\nI will discuss our ongoing studies t
 o identify and characterize communication pathways between major organs in
  Drosophila. Organ-to-organ communications are critical to living systems 
 and play major roles in homeostasis. For example\, the vertebrate CNS rece
 ives information regarding the status of peripheral metabolic processes vi
 a hormonal signaling and direct macromolecular sensing. In addition\, skel
 etal muscles produce various myokines that influence metabolic homeostasis
 \, lifespan\, and the progression of age-related diseases and aging in non
 -muscle tissues.  Using genetic screening\, transcriptome analyses and pro
 teomic approaches\, we are identifying and characterizing secreted factors
  by which organs communicate their physiological state to others in both h
 omeostasis and altered metabolism\, as well as tumor models. These studies
  are providing fundamental insights into how biological processes observed
  in one tissue/organ (e.g.\, decreased cellular metabolism\, mitochondrial
  dysfunction) influence the state of other tissues/organs.\n
LOCATION:https://researchseminars.org/talk/MCB_LUMS/26/
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