BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Mariana Wolfner (Cornell University) DTSTART:20211005T130000Z DTEND:20211005T143000Z DTSTAMP:20260423T024721Z UID:MCB_LUMS/23 DESCRIPTION:Title: Activating eggs and stimulating reproduction: the molecular view from Dr osophila (and beyond).\nby Prof. Dr. Mariana Wolfner (Cornell Universi ty) as part of Colloquium zooming Molecular & Cellular Biology LUMS\n\n\nA bstract\nSuccessful reproduction in internal-fertilizing animals requires molecular modification of both the oocyte and the female. Oocytes must “ activate”\, transitioning from meiotic and molecular arrest to the totip otency of early embryogenesis after fertilization. The female’s physiolo gy must change to support her reproductive success\, egg production\, and her progeny. Versions of these phenomena are universal\, including in huma n fertility and that of insect vectors of diseases like Dengue and Zika. B ut they can be particularly well dissected using model-organisms such as D rosophila fruit flies. This talk will present results from studies using t his model to dissect mechanisms that activate eggs\, and others to elucida te mechanisms that stimulate the female’s reproductive capacity. We will see that egg activation is accompanied by a rise in calcium levels in the egg which\, in turn\, modifies the egg’s proteins to transition to embr yogenesis. We will then consider how the female’s physiological state is modified by seminal proteins that she receives during mating\, and how th ese male-derived proteins act to stimulate her egg production\, including a signal that activates her eggs. The talk will conclude by summarizing ho w these findings inform our understanding of mechanisms of egg activation and seminal protein actions in animals more generally.\n\nOrganizers can b e reached out at 22100032@lums.edu.pk for the Zoom link.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/23/ END:VEVENT END:VCALENDAR