BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Ellen Rothenberg (California Institute of Technology) DTSTART:20210624T040000Z DTEND:20210624T060000Z DTSTAMP:20260423T022803Z UID:MCB_LUMS/22 DESCRIPTION:Title: Gene network and epigenetic mechanisms controlling the generation of T l ymphocytes\nby Prof. Dr. Ellen Rothenberg (California Institute of Tec hnology) as part of Colloquium zooming Molecular & Cellular Biology LUMS\n \n\nAbstract\nT lymphocytes are vital components of the immune system in h umans and other mammals. They are generated by multiple waves of blood ce ll precursors that migrate from the bone marrow to a special organ\, the t hymus\, where the stem cell-like precursor cells encounter signals that ca use them to differentiate into T cells. This process is important for heal th by providing resistance to infection and cancer\, and it is also very i lluminating as a model system to show how environmental signaling\, endoge nously expressed transcription factors\, and epigenetic chromatin changes can work together in an orderly\, stepwise process to convert cells effici ently from stem-like cells to effective\, useful differentiated cells. We can “zoom in” to observe and dissect this process through powerful in vitro culture systems that mimic the thymus in an open format\, which all ows the developing cells to be observed and manipulated. \nThe Rothenberg lab has focused on answering three kinds of questions. First\, how do the transcription factors in these cells act in a cascade\, so that each tran scription factor works to activate or shut off other transcription factors in an orderly way\, which then themselves change the expression of anothe r set of genes? Second\, how does the epigenetic state of the chromatin a ffect what these transcription factors can do at a given stage\, and how d o the factors themselves alter the epigenetic state to allow differentiati on to proceed? Third\, how do these mechanisms explain the high efficiency but slow speed of this developmental process? The talk will show how rec ent results shed light on these questions.\n\nOrganizers can be contacted at 22100032@lums.edu.pk for the Zoom link.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/22/ END:VEVENT END:VCALENDAR