BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Shiv Grewal (National Institutes of Health) DTSTART:20210526T120000Z DTEND:20210526T130000Z DTSTAMP:20260423T035746Z UID:MCB_LUMS/21 DESCRIPTION:Title: Epigenetic genome control by RNA-based mechanisms\nby Prof. Dr. Shiv Grewal (National Institutes of Health) as part of Colloquium zooming Mole cular & Cellular Biology LUMS\n\n\nAbstract\nGenome-wide sequencing of the human genome and several model organisms has greatly facilitated research into genome structure and function. Much attention is now focused on und erstanding how the functional organization of the genome supports translat ion of genetic information into formation of different cell types during d evelopment\, and how it contributes to disease progression. We have shown previously that distinct histone methylation patterns organize chromosome s into “open” euchromatin (H3K4me) and “closed” heterochromatin (H 3K9me) domains\, to modulate use of the genome. Our work has also reveale d that heterochromatin can be targeted by RNAi machinery and/or by pathway s requiring RNA elimination and transcription termination factors. Moreov er\, we find that RNA processing factors and heterochromatin machinery are part of an adaptive cellular mechanisms that can reprogram the genome in response to changes in environmental growth conditions and developmental s ignals. Our most recent work on the assembly and epigenetic inheritance o f silenced chromatin domains\, essential for proper gene regulation during development will be presented.\n\nThe organizers can be contacted at 2210 0032@lums.edu.pk for the zoom link.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/21/ END:VEVENT END:VCALENDAR