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SUMMARY:Prof. Dr. Robert Weinberg (Massachusetts Institute of Technology)
DTSTART:20210311T140000Z
DTEND:20210311T150000Z
DTSTAMP:20260423T022808Z
UID:MCB_LUMS/20
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MCB_LUMS/20/
 ">Mechanisms of the Malignant Progression of Carcinomas</a>\nby Prof. Dr. 
 Robert Weinberg (Massachusetts Institute of Technology) as part of Colloqu
 ium zooming Molecular & Cellular Biology LUMS\n\n\nAbstract\nThe formation
  of primary tumors depends in no small part on the acquisition by evolving
  primary tumor cells of a series of somatically mutated alleles.  However\
 , the last step of tumor progression involves the processes of invasion an
 d metastasis and it has been less clear precisely how these traits are acq
 uired. As will be described\, these phenotypes of high-grade malignancy ar
 e consequences of the actions of non-genetic\, i.e\,\, epigenetic changes 
 in cancer cells that are mediated by induction of the cell-biological prog
 ram termed the epithelial-mesenchymal transition\, which confers many of t
 he traits that are associated traditionally with the changes associated wi
 th the carcinoma cells of high-grade tumors. In addition\, induction of th
 is program is associated with the acquisition of stemness\, that is\, tumo
 r-initiating potential\, which is essential for successful metastasis form
 ation. These various non-genetic processes will be discussed!\n
LOCATION:https://researchseminars.org/talk/MCB_LUMS/20/
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