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SUMMARY:Prof. Dr. Susan Gasser (Freidrich Miescher Institute for Biomedica
 l Research)
DTSTART:20200827T080000Z
DTEND:20200827T100000Z
DTSTAMP:20260423T021752Z
UID:MCB_LUMS/2
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/MCB_LUMS/2/"
 >How and where to assemble heterochromatin\, and why it is essential for o
 rganismal survival</a>\nby Prof. Dr. Susan Gasser (Freidrich Miescher Inst
 itute for Biomedical Research) as part of Colloquium zooming Molecular & C
 ellular Biology LUMS\n\n\nAbstract\nThe establishment and maintenance of c
 hromatin domains shape the epigenetic memory of a cell\, with histone H3 l
 ysine 9 methylation (H3K(me) defining repressed heterochromatin. In C. ele
 gans\, SET-25 (SUV39/g9a) catalyzes to its targets. One requires recogniti
 on of MET-2-mediated H3K9me2 by the MBT-domain protein LIN-61. The second 
 depends on a somatic Argonaut NRDE-3 and 22nt siRNAs. This MET-2-independe
 nt pathway makes up ~10% of SET-25 target sequences\, and most notably inc
 ludes intact transposons. Compared to single mutants\, met-2\;nrde-3 doubl
 e mutant enhances transposon transcription and embryonic lethality. Wherea
 s the targeting of SET-25 silences transposons\, whose expression compromi
 ses development\, the targeting of MET-2/SET-DB1 is necessary to prevent t
 he promiscuous transcription of simple repeats. Simple repeat transcripts 
 lead to R-loops and fork-associated damage\, that requires BRCA1 to ensure
  survival. While the genome becomes unstable\, met-2 mutants show nearly n
 ormal developmental and differentiation patterns.\n
LOCATION:https://researchseminars.org/talk/MCB_LUMS/2/
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