BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Dirk Schubeler (Friedrich Miescher Institute for Biomedi cal Research) DTSTART:20210421T080000Z DTEND:20210421T090000Z DTSTAMP:20260423T022805Z UID:MCB_LUMS/19 DESCRIPTION:Title: Finding your place: Transcription factors as sensors and modifiers of ch romatin\nby Prof. Dr. Dirk Schubeler (Friedrich Miescher Institute for Biomedical Research) as part of Colloquium zooming Molecular & Cellular B iology LUMS\n\n\nAbstract\nTranscription factors only bind a minority of t heir motifs in large mammalian genomes. One potential explanation is that many motifs are not accessible for binding due to the action of chromatin and DNA methylation. We are using mammalian stem cell models to understand this important interplay between gene regulation\, chromatin structure an d DNA methylation. We study the dynamics of the epigenome and test regulat ory models in cellular models by genetic perturbation and genome editing a pproaches. I will discuss our recent efforts in understanding how the sens itivity to DNA methylation can limit transcription factor binding in the c ontext of the cell\, the identification of a novel\, strong activating fac tor and how transcripton factors rely on specific chromatin remodelers for access to their binding sites.\n\nOrganizers can be contacted at m.tariq@ lums.edu.pk or 22100032@lums.edu.pk for the zoom link\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/19/ END:VEVENT END:VCALENDAR