BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Wendi Bickmore (University of Edinburgh) DTSTART:20210407T100000Z DTEND:20210407T110000Z DTSTAMP:20260423T022804Z UID:MCB_LUMS/18 DESCRIPTION:Title: The role of spatial proximity in genome regulation\nby Prof. Dr. Wen di Bickmore (University of Edinburgh) as part of Colloquium zooming Molecu lar & Cellular Biology LUMS\n\n\nAbstract\nImaging and genomic technologie s have opened up large-scale interrogation of 3D genome organisation in th e cell nucleus. This has revealed multiple layers of organisation and at d ifferent scales\, including distal interactions of genome compartments\, t opologically associating domains (TADs) and specific cis interactions betw een either active or repressive elements. Progress is being made toward un derstanding the molecular mechanisms that mediate these layers of organisa tion. However\, understanding the functional significance of 3D organisati on across genomic scales lags behind. To what extent does 3D organisation drive genome regulation\, or are some aspects of 3D organisation simply an emergent property of genome and protein functions? In this talk I will de scribe our efforts to determine the functional significance of the 3D geno me – from the action of polycomb complexes in bridging distal interactio ns between repressed loci\, to the role of TADs and enhancer-promoter prox imity in enhancer-driven gene activation.\n\nOrganizers can be contacted a t m.tariq@lums.edu.pk or 22100032@lums.edu.pk for the zoom link.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/18/ END:VEVENT END:VCALENDAR