BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Denis Duboule (University of Geneva) DTSTART:20210322T090000Z DTEND:20210322T100000Z DTSTAMP:20260423T022804Z UID:MCB_LUMS/17 DESCRIPTION:Title: Hox gene regulation in embryos and pseudo-embryos\nby Prof. Dr. Deni s Duboule (University of Geneva) as part of Colloquium zooming Molecular & Cellular Biology LUMS\n\n\nAbstract\nDuring vertebrate development\, clus tered Hox genes are activated in a precise time-sequence\, leading to patt erns necessary to properly establish the body plan. The mechanism underlyi ng this in cis timing phenomenon has remained unknown ever since its obser vation in 1989\, due to the difficulty to approach it using early gastrula ting mouse embryos. I will discuss an alternative possibility\, which is t o use pseudo-embryos produced out of ES cells (referred to as gastruloids) to address this now 30 years old question and will show some preliminary data indicating that this system may allow us to more efficiently tackle t his issue in the next few years to come.\n\nOrganizers can be contacted at m.tariq@lums.edu.pk or 22100032@lums.edu.pk for the zoom link.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/17/ END:VEVENT END:VCALENDAR