BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Susan Wessler (University of California Riverside) DTSTART:20210224T040000Z DTEND:20210224T050000Z DTSTAMP:20260423T024736Z UID:MCB_LUMS/14 DESCRIPTION:Title: Understanding the strategies evolved by a very successful transposable e lement\nby Prof. Dr. Susan Wessler (University of California Riverside ) as part of Colloquium zooming Molecular & Cellular Biology LUMS\n\n\nAbs tract\nTransposable elements (TEs) achieve high copy numbers through waves of amplification called bursts.\nFor a TE to successfully burst it must b e able to significantly increase its copy number without killing its\nhost or being silenced by genome surveillance (epigenetic) mechanisms. However \, because the vast majority of TE\nbursts have been inferred after the fa ct – via computational analysis of whole genome sequence – the\nstealt h features they require for success have remained largely undiscovered. So me features have recently\nbeen discovered by analyzing active bursts of t he miniature inverted repeat transposable element (MITE)\nmPing and its au tonomous partner Ping in four strains of domesticated rice (Oryza sativa\, temperate\njaponica). First\, mPing targets genic regions but avoids exon sequences\, thus minimizing harm to the\nhost. Second\, because mPing doe s not share coding sequences with Ping\, increases in its copy number and\ nhost recognition of its sequences do not silence Ping genes\, thus allowi ng the continuous production of\nthe proteins necessary to sustain the bur st for decades.\n\nAdditional insights into the mPing burst comes from ana lyses of an extensive collection of rice genomes\nincluding 3000 domestica ted strains and a recombinant inbred population. While the survey of 3000\ nstrains revealed that the burst is very recent and is restricted to a few closely related accessions\, analysis\nof the sequences of 272 recombinan t inbred lines demonstrated the potential of mPing to rapidly spread\nunim peded through a large population and increase the frequency of structural variations.\n\nOrganizers can be contacted at m.tariq@lums.edu.pk or 22100 032@lums.edu.pk for the zoom link.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/14/ END:VEVENT END:VCALENDAR