BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Mitzi Kuroda (Harvard University) DTSTART:20210201T130000Z DTEND:20210201T140000Z DTSTAMP:20260423T024721Z UID:MCB_LUMS/12 DESCRIPTION:Title: Bivalent Polycomb Complexes as Master Switches of Developmental Gene Reg ulation\nby Prof. Dr. Mitzi Kuroda (Harvard University) as part of Col loquium zooming Molecular & Cellular Biology LUMS\n\n\nAbstract\nThe genom es of higher organisms are annotated by chromosomal proteins and histone m odifications\, which delineate active genes\, regulatory elements\, and si lent regions. This annotation is critical for proper cell type specificati on\, and an ongoing challenge is to decipher the rules that establish and maintain chromatin organization. Our studies of the highly conserved Polyc omb group (PcG) epigenetic regulators in Drosophila has led my lab to prop ose a model in which the Polycomb Repressive Complex 1 (PRC1) and classica l co-activators form ‘bivalent’ protein complexes on transcriptionally poised developmental genes. We speculate that these function as ‘master switches’ that are responsive to the amount of local acetylation or dea cetylation activities recruited by cell type specific DNA binding factors\ , leading to stable but reversible activation or repression\, respectively . Our model is based on chromatin crosslinking\, affinity purification\, a nd mass spectrometry experiments\, in which Drosophila PRC1 strongly inter acts with classical co-activators\, dBRD4 and dMOZ. We are currently explo ring potential parallels in mammalian development\n\nOrganizers can be con tacted at m.tariq@lums.edu.pk or 22100032@lums.edu.pk for the zoom link.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/12/ END:VEVENT END:VCALENDAR