BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:Prof. Dr. Oliver Bell (University of Southern California) DTSTART:20200728T160000Z DTEND:20200728T170000Z DTSTAMP:20260423T023939Z UID:MCB_LUMS/1 DESCRIPTION:Title: How cell fate decisions are maintained by Polycomb\nby Prof. Dr. Oliv er Bell (University of Southern California) as part of Colloquium zooming Molecular & Cellular Biology LUMS\n\n\nAbstract\nTranscriptional silencing by Polycomb group (PcG) proteins is a major paradigm for epigenetic inher itance from fly to human. The Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to enforce gene silencing. Howev er\, the mechanisms underlying the inheritence of transcriptional silencin g by different PRC complexes are not known. Addressing this question has b een extremely challenging due to technical limitations that do not discern the initiation from sequence-independent maintenance of repression. We ha ve solved this problem by developing an approach to reversibly recruit PRC 1 or PRC2 to transcriptionally inactive or active chromatin in mouse embry onic stem cells. For the first time\, we directly and systematically inter rogate the ability of different PcG complexes to (1) form repressive chrom atin structure\, (2) initiate gene silencing\, and (3) maintain silencing. I will present an unexpected division of labour between different PRC1 an d PRC2 complexes in epigenetic silencing.\n LOCATION:https://researchseminars.org/talk/MCB_LUMS/1/ END:VEVENT END:VCALENDAR