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SUMMARY:Reidun Twarock (The University of York - UK)
DTSTART:20221216T160000Z
DTEND:20221216T170000Z
DTSTAMP:20260423T041509Z
UID:GEOTOP-A/47
DESCRIPTION:Title: <a href="https://researchseminars.org/talk/GEOTOP-A/47/
 ">Geometry in the Fight against Viral Infection</a>\nby Reidun Twarock (Th
 e University of York - UK) as part of GEOTOP-A seminar\n\n\nAbstract\nThe 
 Covid-19 pandemic has highlighted the need for novel antiviral strategies.
  In this talk\, I will demonstrate that insights into the geometric princi
 ples underpinning virus architecture provide a key to uncovering the mecha
 nisms by which viruses replicate and infect their hosts. Geometric and top
 ological descriptors of virus architecture\, combined with stochastic simu
 lations\, reveal how viruses navigate the knife’s edge between stability
  and instability\, guaranteeing protection for their genetic cargo while a
 lso enabling its timely release. Models of virus architecture also provide
  a novel perspective on open problems in virus assembly. This includes the
  origin and control\nof polymorphic particle assembly\, which arises\, amo
 ngst others\, when virus-derived protein containers are functionalised to 
 present antigens for applications in vaccinology. They moreover play an in
 strumental role in the discovery of genome-encoded virus assembly instruct
 ions. These results shed new light on selective pressures on viral evoluti
 on and pave the way for innovation in antiviral therapy and virus nanotech
 nology.\n
LOCATION:https://researchseminars.org/talk/GEOTOP-A/47/
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