BEGIN:VCALENDAR VERSION:2.0 PRODID:researchseminars.org CALSCALE:GREGORIAN X-WR-CALNAME:researchseminars.org BEGIN:VEVENT SUMMARY:David Lacoste (ESPCI Paris) DTSTART:20240516T140000Z DTEND:20240516T143000Z DTSTAMP:20261007T194104Z UID:AutocatalysisRN/5 DESCRIPTION:Title: Emergence and maintenance of the homochirality of life\nby Dav id Lacoste (ESPCI Paris) as part of Autocatalysis in reaction networks\n\n \nAbstract\nHomochirality is a property common to all chiral molecules (i. e. those that are not superimposable on their mirror image) in living orga nisms\, which means that these molecules are present in only one form (rig ht or left) to the exclusion of the other. Understanding the emergence of homochirality is a central question for the origin of life. \n\nIn a first study\, we have shown that homochirality can generically emerge in a larg e class of autocatalytic chemical networks\, provided the network is large enough (in terms of the number of its chiral species) and driven sufficie ntly far from equilibrium [1\,2]. Polymerization produces a large number o f different molecular species as the length of the polymers increases\, wh ich is why the question of whether — and how — polymerization can supp ort the emergence of homochirality arises naturally. To make progress on t his issue\, we then explored the conditions that permit the emergence and maintenance of homochirality in an RNA reactor via template-directed ligat ion and polymerization [3]. \n\n[1] G. Laurent\, D. Lacoste\, and P. Gaspa rd\, PNAS (2021) 118 (3) e2012741118.\n[2] G. Laurent\, D. Lacoste\, and P . Gaspard\, Proc. R. Soc. A 478:20210590 (2022).\n[3] G. Laurent\, T. Göp pel\, D. Lacoste and U. Gerland\, PRX Life 2\, 013015\n(2024)\n LOCATION:https://researchseminars.org/talk/AutocatalysisRN/5/ END:VEVENT END:VCALENDAR